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Chinese medicine often used Agrimony to treat menstrual difficulties and during the middle ages this herb was used frequently as a sleep aid. In North America agrimony was used for a variety of ailments by Native Americans and up until the late 19th century agrimony was used throughout Europe and North America to treat skin conditions, cough, sore throat, and diarrhea.

The herb has been used extensively in folklore. Witches often used agrimony in spells and to ward off hexes. When placed in a sachet and hung in the home, it was said to provide protection against goblins, evil spirits, and poisoning. Practitioners of voodoo use agrimony to repel jinxes and block curses. It is believed the herb not only repels jinxes and curses, it sends them back against their perpetrator. Today modern day wiccans often place leaves of the plant in pillowcases to ensure a good night's sleep.

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